After impressing in domestic Pakistani cricket, Mohammad Asif was fast tracked into the Pakistan test squad and made his first appearance against Australia in January 2005. He bowled 18 overs without taking a wicket and Australia won by 9 wickets.
Asif was subsequently dropped from the side but returned a year later in January 2006 for the home tour against India. In the second Test, Asif bowled 34 overs and took the wicket of Yuvraj Singh. It was the third Test in Karachi, however, where Asif would make headlines. After a poor batting display by Pakistan, Asif took 4 for 78 in the first innings, including the wickets of V. V. S. Laxman, Rahul Dravid and, once again, Yuvraj Singh, to help Pakistan take a six-run lead. Asif returned in the second innings with three clean bowled wickets of Virender Sehwag, Laxman, and Sachin Tendulkar to lead Pakistan to victory. His series against the Indians was blighted by a fine imposed by match referee Chris Broad for overappealing and premature celebration of a wicket.