Gayle played for the West Indies at youth international level after he made his first-class debut aged 19 for Jamaica. He played his first One Day International 11 months later, and his first Test match 6 months after that.

Gayle, who normally opens the innings when he plays for the West Indies, is a destructive batsman who is most effective playing square of the wicket. In July 2001, Gayle (175), together with Daren Ganga (89) established the record for opening partnerships at Queens Sports Club, Bulawayo when they put on 214 together against Zimbabwe.